Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Detrol, Detrol LA
Tolterodine is a muscarinic receptor antagonist used to treat overactive bladder (OAB). It works by blocking the action of acetylcholine, a neurotransmitter that stimulates bladder muscle contractions. This helps to reduce urinary urgency, frequency, and incontinence. It belongs to a class of drugs known as anticholinergics/antimuscarinics.
For the treatment of overactive bladder symptoms, including urinary urgency, frequency, and urge incontinence.
Outcome:
Increased tolterodine levels, leading to potential side effects.
Mechanism:
Ketoconazole inhibits CYP3A4, the enzyme responsible for metabolizing tolterodine.
Outcome:
Potential for altered warfarin effect (although clinical significance is debated).
Mechanism:
Competition for metabolism via CYP2D6.
Outcome:
Potential for slightly increased tolterodine levels.
Mechanism:
Minor inhibition of CYP2D6.
Most likely new formulation: Transdermal patch (Year: 2026, 30% confidence)
Based on current usage trends and clinical trial data, there is a low probability (<5%) of a major label change or new black box warning being issued within the next 2 years.
Muscarinic Receptor Antagonist, Anticholinergic
Tertiary Amine