Medicines
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Discover all available medicines and treatments
Brand: Mavik
Trandolaprilat is the active metabolite of trandolapril, an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This action leads to vasodilation, reducing blood pressure and workload on the heart. Trandolaprilat is primarily used to treat hypertension (high blood pressure) and congestive heart failure.
Used to treat hypertension and congestive heart failure.
Fetal toxicity. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death.
Outcome:
Hyperkalemia
Mechanism:
Reduced potassium excretion
Outcome:
Hypotension
Mechanism:
Additive hypotensive effects
Outcome:
Reduced absorption of trandolapril
Mechanism:
Unknown
Most likely new formulation: Extended-release formulation (2025, 60% confidence)
Based on usage patterns and clinical trial data, there is a low likelihood of any major regulatory changes in the next 5 years.
ACE Inhibitor, Antihypertensive
Non-sulfhydryl-containing ACE inhibitor