Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Parnate
Tranylcypromine is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) primarily used to treat major depressive disorder (MDD), particularly atypical depression. It belongs to the class of antidepressants and functions by preventing the breakdown of neurotransmitters like serotonin, norepinephrine, and dopamine in the brain, thereby increasing their availability.
Used to treat major depressive disorder, particularly atypical depression.
Tranylcypromine sulfate can cause hypertensive crises that may be fatal. These crises may be precipitated by foods rich in tyramine or tryptophan or by concurrent medications.
Outcome:
Hypertensive crisis
Mechanism:
Increased tyramine levels due to MAO inhibition
Outcome:
Hypertensive crisis
Mechanism:
Possible serotonergic and dopaminergic effects
Outcome:
Increased anxiety, insomnia
Mechanism:
Increased norepinephrine and dopamine levels
Most likely new formulation: Extended-release formulation (2026, 30% confidence)
Based on current usage trends and ongoing research on MAOIs, there is a low (5%) likelihood of any major regulatory changes regarding tranylcypromine in the near future.
Antidepressant, Monoamine Oxidase Inhibitor (MAOI)
Cyclopropylamine