Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Desyrel, Oleptro, Trazorel, Trittico
Trazodone is an atypical antidepressant primarily used to treat major depressive disorder. It belongs to the serotonin antagonist and reuptake inhibitor (SARI) class and affects serotonin levels in the brain. While initially classified as a triazolopyridine derivative, its mechanism of action distinguishes it from other antidepressants like tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). Trazodone has sedative effects and is often prescribed off-label for insomnia.
For treating major depressive disorder and off-label for insomnia.
Outcome:
Serotonin syndrome
Mechanism:
Increased serotonin levels
Outcome:
Increased digoxin levels
Mechanism:
Unknown
Outcome:
Potential for serotonin syndrome
Mechanism:
Additive serotonergic effects
Most likely new formulation: Extended-release trazodone for improved adherence and reduced side effects (2026, 60% confidence)
Based on usage trends and emerging research on novel antidepressants, there is a 20% likelihood of a new extended-release formulation of trazodone being approved within the next 5 years.
Serotonin antagonist and reuptake inhibitor (SARI)
Triazolopyridine