Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Artane, Apo-Trihex, Parkin, Pacitane
Trihexyphenidyl, an anticholinergic medication, is primarily used to manage the symptoms of Parkinson's disease and drug-induced parkinsonism. It acts by blocking the neurotransmitter acetylcholine, thereby helping to balance the levels of acetylcholine and dopamine in the brain, reducing tremors, muscle rigidity, and slow movements. It belongs to the class of anticholinergics known as antimuscarinics.
For treating Parkinson's disease symptoms and drug-induced parkinsonism.
Outcome:
Increased anticholinergic adverse effects
Mechanism:
Additive anticholinergic effects
Outcome:
Increased dyskinesias
Mechanism:
Dopamine-acetylcholine imbalance
Outcome:
Decreased trihexyphenidyl absorption
Mechanism:
Altered gastric pH
Most likely new formulation: Extended-release capsules (Year 2026, 60% confidence)
Based on current usage trends and patent expirations, there is a 20% likelihood of generic trihexyphenidyl formulations entering the market within the next 5 years.
Anticholinergic, Antimuscarinic
Tertiary amine anticholinergic