Medicines
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Discover all available medicines and treatments
Brand: Tridione, Petimal
Trimethadione is an anticonvulsant medication primarily used to treat absence seizures, a type of generalized epilepsy. It belongs to the oxazolidinedione class of drugs and works by reducing abnormal electrical activity in the brain. While once a common treatment for absence seizures, its use has declined due to potential side effects and the availability of safer alternatives.
Used to treat absence seizures.
Trimethadione carries a Black Box Warning for serious side effects including aplastic anemia, agranulocytosis, and nephrotic syndrome. It is also associated with birth defects and should not be used during pregnancy.
Outcome:
Increased risk of trimethadione toxicity
Mechanism:
Valproic acid inhibits trimethadione metabolism.
Outcome:
Altered seizure control
Mechanism:
Pharmacokinetic interactions.
Outcome:
Potential for decreased lamotrigine levels
Mechanism:
Trimethadione may induce lamotrigine metabolism
Most likely new formulation: Extended-release formulation to improve adherence (Year: Unlikely, <1% confidence).
Based on declining usage trends and safety concerns, the likelihood of new trimethadione formulations being developed is low (<5%).
Anticonvulsant, Oxazolidinedione
Oxazolidinedione