Medicines
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Discover all available medicines and treatments
Brand: Navoban, Nevatrop, Tropisetron Bluefish
Tropisetron is a serotonin 5-HT3 receptor antagonist used primarily to prevent nausea and vomiting, particularly those induced by chemotherapy and radiotherapy. It belongs to the class of antiemetics and acts by blocking the action of serotonin at 5-HT3 receptors, which are located in the central nervous system and the gastrointestinal tract. These receptors play a crucial role in the vomiting reflex.
For prevention and treatment of nausea and vomiting associated with chemotherapy and radiotherapy.
Outcome:
Increased risk of QT prolongation and torsades de pointes
Mechanism:
Additive effects on QT interval prolongation
Outcome:
Increased tropisetron levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Decreased tropisetron levels
Mechanism:
Induction of CYP3A4 metabolism
Most likely new formulation: Extended-release oral formulation (2025, 70% confidence)
Based on current usage trends and patent expirations, the market share of tropisetron is predicted to decrease by 5% in the next 3 years.
Antiemetic, Serotonin 5-HT3 Receptor Antagonist
Indazole derivative