Medicines
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Discover all available medicines and treatments
Brand: Vallergan, Theralene, Anergan
Vallergan, generically known as alimemazine, is a first-generation antihistamine belonging to the phenothiazine class. It possesses sedative, anticholinergic, antiemetic, and weak antihistaminic properties. Primarily prescribed for insomnia and allergies in children, it functions by blocking histamine H1 receptors and exhibiting some anticholinergic effects. It is also occasionally used for preoperative sedation due to its calming and sedative properties.
Used for insomnia in children, allergies, and occasionally as a pre-operative sedative.
Outcome:
Increased sedation and drowsiness
Mechanism:
Additive CNS depressant effects
Outcome:
Increased risk of orthostatic hypotension
Mechanism:
Additive hypotensive effects
Outcome:
Reduced absorption of alimemazine
Mechanism:
Chelation or altered gastric pH
Most likely new formulation: Extended-release formulation for improved sleep quality (Year: 2026, 30% confidence)
Due to the limited availability of recent clinical data and lack of FDA approval in some regions, there is a low (5%) likelihood of a significant change in its regulatory status in the next 5 years.
Antihistamine, Phenothiazine
Phenothiazine