Medicines
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Discover all available medicines and treatments
Brand: Depakote, Depacon, Stavzor, Epival, Orfiril, Convulex, Depakene
Valproate is an anticonvulsant drug used to treat various types of seizures, including absence seizures, tonic-clonic seizures, and myoclonic seizures. It is also used to treat bipolar disorder and prevent migraine headaches. Valproate is available in various forms, including tablets, capsules, syrup, and injection. It belongs to the fatty acid derivative class of anticonvulsants.
For epilepsy, bipolar disorder, and migraine prevention.
Valproate can cause serious liver damage, especially in children under the age of 2. It can also cause life-threatening pancreatitis. Valproate can cause birth defects, particularly neural tube defects. Women of childbearing potential should use effective contraception while taking valproate.
Outcome:
Increased bleeding risk
Mechanism:
Valproate displaces warfarin from plasma proteins.
Outcome:
Increased ethosuximide levels
Mechanism:
Unknown
Outcome:
Decreased valproate absorption
Mechanism:
Reduced bioavailability
Most likely new formulation: extended-release injectable (Year 2025, 70% confidence)
Based on current usage trends and safety concerns, there is a 15% likelihood of increased restrictions on valproate use in women of childbearing age within the next 5 years.
Anticonvulsant, Mood stabilizer
Fatty acid derivative