Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Javlor
Vinflunine is a semi-synthetic vinca alkaloid used in the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of platinum-containing chemotherapy. It belongs to the class of microtubule inhibitors, specifically targeting the mitotic spindle, thereby disrupting cell division and leading to apoptosis (programmed cell death) in cancer cells.
For the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of platinum-containing chemotherapy.
Outcome:
Increased vinflunine levels, leading to increased risk of toxicity.
Mechanism:
Inhibition of vinflunine metabolism.
Outcome:
Potential for decreased effectiveness of the vaccine.
Mechanism:
Immunosuppression.
Outcome:
Potential for decreased vinflunine absorption.
Mechanism:
Altered gastrointestinal pH.
Most likely new formulation: nanoparticle delivery system (Year: 2026, 30% confidence)
Based on current usage trends and clinical trial data, there is a low likelihood of significant changes to the regulatory status of vinflunine in the next 5 years.
Antineoplastic Agent, Microtubule Inhibitor, Vinca Alkaloid
Vinca Alkaloid