Medicines
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Discover all available medicines and treatments
Brand: Sonata
Zaleplon is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class used for the short-term treatment of insomnia, specifically difficulty with sleep onset. It acts on the benzodiazepine receptor, specifically the BZ1 subtype, which is believed to be primarily responsible for mediating sedation. Unlike some other hypnotics, zaleplon has a short half-life, which can minimize daytime drowsiness.
For short-term treatment of insomnia characterized by difficulty with sleep onset.
Outcome:
Increased sedation and respiratory depression
Mechanism:
Synergistic CNS depressant effects
Outcome:
Increased sedation
Mechanism:
Additive CNS depression
Outcome:
Delayed absorption
Mechanism:
Altered gastric emptying
Most likely new formulation: Extended-release zaleplon for improved sleep maintenance (2026, 60% confidence)
Based on current usage trends and emerging therapies, zaleplon prescriptions are predicted to decline by 5% over the next five years.
Hypnotic, Nonbenzodiazepine
Pyrazolopyrimidine