Medicines
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Discover all available medicines and treatments
Brand: Geodon, Zeldox, Ziprasol
Ziprasidone is an atypical antipsychotic medication primarily used to treat schizophrenia and bipolar disorder. It acts as an antagonist at multiple serotonin, dopamine, and alpha-adrenergic receptors in the brain, modulating neurotransmission and alleviating symptoms of psychosis and mania. Ziprasidone is available in various formulations, including capsules, tablets, and an intramuscular injection for acute agitation.
For schizophrenia, bipolar disorder, and acute agitation.
Increased mortality in elderly patients with dementia-related psychosis.
Outcome:
Reduced ziprasidone levels
Mechanism:
CYP3A4 induction
Outcome:
Increased sedation
Mechanism:
Additive CNS depressant effects
Outcome:
Reduced ziprasidone efficacy
Mechanism:
Antagonism at adenosine receptors
Most likely new formulation: Extended-release injectable (2026, 60% confidence)
Based on current usage trends and clinical trial data, there is a 70% likelihood of ziprasidone maintaining its current FDA approval status for the next 5 years.
Atypical Antipsychotic
Benzisothiazolylpiperazine