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Abdelkader E. Ashour
Associate Professor at Kulliyyah of Medicine, Department of Basic Medical Sciences
Enzyme Function And Inhibition
Immune Cell Function And Interaction
Immunology
Oncology
Quinazolinone Synthesis And Applications
2.0K
Citations
27
H-index
0
Patents
90
Publications
0
Grants
$0
Total Funding
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Research Contributions
Developed Docetaxel Chitosan-Coated Nanoparticles for Enhanced Cytotoxicity
Engineered novel docetaxel chitosan-coated PLGA/PCL nanoparticles, demonstrating magnified cytotoxicity and bioavailability in cancer treatment.
Biomedicine & Pharmacotherapy (2018)
Elucidated TNF-α and NF-κB Regulation via Histamine 4 Receptor in Joint Inflammation
Demonstrated the regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of the histamine 4 receptor in a rat model of LPS-induced joint inflammation.
Immunobiology (2015)
Demonstrated Thymoquinone's Anti-Cancer Effects on Hepatocellular Carcinoma
Showed that thymoquinone suppresses human hepatocellular carcinoma cell growth by inhibiting IL-8 expression, elevating TRAIL receptors, inducing oxidative stress, and promoting apoptosis.
Molecular and Cellular Biochemistry (2014)
Revealed Metformin's Protective Role Against Doxorubicin-Induced Myocardial Damage
Discovered that metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats.
Oxidative Medicine and Cellular Longevity (2012)
Identified Semaphorin 5A as a Promoter of Pancreatic Cancer Growth and Metastasis
Found that high gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion, and metastasis.
International Journal of Cancer (2010)
Investigated the Anti-Arthritic Effects of Naringin
Demonstrated that naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κB, STAT3, and pro-inflammatory mediators.
Inflammation (2014)
Developed Carbonic Anhydrase Inhibitors for Tumor Therapy
Synthesized benzenesulfonamides incorporating cyanoacrylamide moieties as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII.
Bioorganic & Medicinal Chemistry (2012)
Explored the Role of Histamine 4 Receptor in Rheumatoid Arthritis
Investigated the involvement of the histamine 4 receptor in the pathogenesis and progression of rheumatoid arthritis.
International Immunology (2014)
Research Highlights
Abdelkader E. Ashour is an accomplished researcher specializing in pharmacology, immunology, and cancer research, with a focus on drug discovery and the development of novel therapeutic interventions. His work explores the interplay of inflammation, oxidative stress, and apoptosis in various disease models, contributing significantly to the understanding of disease mechanisms and potential treatments.
Research Areas
Enzyme Function And InhibitionImmune Cell Function And InteractionImmunologyOncologyQuinazolinone Synthesis And Applications
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