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Bo Wang
Researcher at Department of Integrative Structural and Computational Biology
Cell Death Mechanisms And Regulation
Interferon And Immune Responses
Phagocytosis And Immune Regulation
Rna Modifications And Cancer
Sars-Cov-2 And Covid-19 Research
3.6K
Citations
31
H-index
0
Patents
95
Publications
6
Grants
$2,071,663
Total Funding
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Research Contributions
Peroxisomal Role in ROS/RNS Metabolism
Demonstrated the critical role of peroxisomes in reactive oxygen and nitrogen species metabolism and its implications for human diseases.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2011)
Genome Sequencing of Salvia miltiorrhiza
Contributed to the analysis of the genome sequence of the medicinal plant Salvia miltiorrhiza, providing insights into its bioactive compounds.
Molecular Plant (2016)
SARS-CoV-2 Antibody Efficacy
Identified and characterized a structurally resolved SARS-CoV-2 antibody with high efficacy in severely infected hamsters, informing potent antibody cocktail strategies.
Cell (2020)
Mn2+ Activation of cGAS
Discovered that Mn2+ directly activates cGAS, revealing a noncanonical catalytic synthesis of 2'3'-cGAMP and its implications for immune signaling.
Cell Reports (2020)
ALKBH5 as a Pan-Cancer Biomarker
Demonstrated that ALKBH5 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types, including gliomas.
Frontiers in Immunology (2022)
PHF5A Acetylation in Colorectal Cancer
Showed that acetylation of PHF5A modulates stress responses and colorectal carcinogenesis through alternative splicing-mediated upregulation of KDM3A.
Molecular Cell (2019)
m6A Methylome in Colorectal Cancer
Performed a comprehensive analysis of the transcriptome-wide m6A methylome in colorectal cancer by MeRIP sequencing, identifying potential therapeutic targets.
Epigenetics (2020)
KIAA1429 in Lung Adenocarcinoma
Identified KIAA1429 as a promoter of tumorigenesis and gefitinib resistance in lung adenocarcinoma by activating the JNK/MAPK pathway in an m6A-dependent manner.
Drug Resistance Updates (2022)
Research Highlights
Bo Wang is a leading researcher in integrative structural and computational biology, focusing on RNA modifications, immune responses, and cancer, with significant contributions to understanding SARS-CoV-2 and developing therapeutic antibodies. His work bridges structural biology, immunology, and cancer biology, leading to advancements in diagnostics and therapeutic strategies.
Research Areas
Cell Death Mechanisms And RegulationInterferon And Immune ResponsesPhagocytosis And Immune RegulationRna Modifications And CancerSars-Cov-2 And Covid-19 Research
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