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Dawn Coverley
Researcher at Research Department
Artificial Intelligence
Cancer-Related Molecular Pathways
Genetics
Rna Research And Splicing
1.9K
Citations
21
H-index
0
Patents
57
Publications
0
Grants
$0
Total Funding
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Research Contributions
Identified distinct roles for cyclins E and A in DNA replication complex assembly
Demonstrated the specific functions of cyclins E and A during the assembly and activation of DNA replication complexes, providing insights into cell cycle control.
Nature Cell Biology (2002)
Elucidated the role of SSB in human DNA excision repair
Showed the requirement for single-stranded DNA binding protein (SSB) in human DNA excision repair, contributing to understanding of DNA repair mechanisms.
Nature (1991)
Characterized CIZ1 as a DNA-binding coactivator of the estrogen receptor α
Identified CIZ1 as a novel coactivator of the estrogen receptor α, conferring hypersensitivity to estrogen action and implicating it in cancer development.
Cancer Research (2006)
Discovered variant Ciz1 as a circulating biomarker for early-stage lung cancer
Identified a variant of Ciz1 as a potential circulating biomarker for the early detection of lung cancer, leading to the development of diagnostic tools.
Proceedings of the National Academy of Sciences (2012)
Demonstrated that prion-like domains drive CIZ1 assembly formation at the inactive X chromosome
Showed that prion-like domains within CIZ1 are crucial for its assembly and localization at the inactive X chromosome, influencing epigenetic regulation.
The Journal of Cell Biology (2022)
Revealed the role of CIZ1 in maintaining the epigenetic landscape
Demonstrated that CIZ1 is essential for maintaining the epigenetic landscape and that its absence leads to epigenetic instability and transformation in differentiated fibroblasts.
Nature Communications (2019)
Identified DHX9 as a cell cycle regulated nucleolar recruitment factor for CIZ1
Discovered that DHX9 regulates the recruitment of CIZ1 to the nucleolus during the cell cycle, providing insights into the dynamic localization of CIZ1.
Scientific Reports (2020)
Research Highlights
Dawn Coverley is a distinguished cell biologist at the University of York, renowned for her work on DNA replication, repair mechanisms, and the role of CIZ1 in cancer and epigenetic regulation; she is also the founder of Cizzle Biotechnology, focused on early lung cancer detection.
Research Areas
Artificial IntelligenceCancer-Related Molecular PathwaysGeneticsRna Research And Splicing
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