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Emma Stewart
Associate Lecturer at Biology
Artificial Intelligence
Genetics
Rna Research And Splicing
699
Citations
6
H-index
0
Patents
13
Publications
0
Grants
$0
Total Funding
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Research Contributions
CIZ1 Facilitates Xist RNA Localization
Demonstrated that the nuclear matrix protein CIZ1 facilitates the localization of Xist RNA to the inactive X-chromosome territory, contributing to understanding X-chromosome inactivation.
Genes & Development (2017)
CIZ1 and Epigenetic Landscape Maintenance
Showed that CIZ1 is required for the maintenance of the epigenetic landscape and that this maintenance is corrupted in differentiated fibroblasts in long-term culture.
Nature Communications (2019)
CIZ1-F Overrepresentation in Early Stage Tumors
Identified that CIZ1-F, an alternatively spliced variant of CIZ1, is overrepresented in early-stage common solid tumors, suggesting its potential role in cancer development.
Cell Cycle (2018)
Epigenetic Instability Driven by CIZ1 Fragments
Discovered that dominant CIZ1 fragments drive epigenetic instability and are expressed in early-stage cancers, highlighting their potential as therapeutic targets.
bioRxiv (Cold Spring Harbor Laboratory) (2023)
CIZ1-RNA Disruption in Breast Cancers
Revealed that epigenetic deprogramming occurs through the disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers, providing insights into epigenetic mechanisms in cancer.
The Journal of Cell Biology (2025)
CIZ1 Localization to the Inactive X Chromosome
Demonstrated that the nuclear matrix protein CIZ1 is localized to the inactive X chromosome, and its absence leads to loss of Xist localization and female-specific lymphoproliferative disorder in mice.
Molecular Biology of the Cell (2016)
Research Highlights
Emma Stewart investigates the role of CIZ1 in epigenetic maintenance and its disruption in early-stage cancers, with a focus on RNA nuclear assemblies and epigenetic instability. Her research contributes to understanding cancer development and potential therapeutic targets.
Research Areas
Artificial IntelligenceGeneticsRna Research And Splicing
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