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Greta Pintacuda
Researcher at Research Department
Bioinformatics
Crispr And Genetic Engineering
Genetics
Rna Modifications And Cancer
Rna Research And Splicing
2.7K
Citations
17
H-index
0
Patents
35
Publications
0
Grants
$0
Total Funding
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Research Contributions
Identified factors required for Xist RNA-mediated silencing using a pooled shRNA screen.
Conducted a pooled shRNA screen to identify Rbm15, Spen, and Wtap as critical factors for Xist RNA-mediated silencing, contributing to the understanding of X chromosome inactivation.
Cell Reports (2015)
Revealed the role of hnRNPK in recruiting PRC1 to the Xist RNA B-Repeat.
Demonstrated that hnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to establish Polycomb-mediated chromosomal silencing, providing insights into the mechanisms of X chromosome inactivation.
Molecular Cell (2017)
Showed that PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.
Published research demonstrating that PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation, furthering the understanding of this crucial process.
Science (2017)
Investigated the role of SmcHD1 in antagonizing TAD formation on the inactive X chromosome.
Showed that the non-canonical SMC protein SmcHD1 antagonizes TAD formation and compartmentalization on the inactive X chromosome, contributing to the understanding of X chromosome structure.
Nature Communications (2018)
Developed an iPSC-based platform for studying autism spectrum disorders.
Utilized induced pluripotent stem cell (iPSC) models to study autism spectrum disorders, bridging the gap between genetic discoveries and perturbed pathways, and identifying potential therapeutic targets.
Cell Genomics (2023)
Developed Genoppi, an open-source software for integrating proteomic and genetic data.
Developed Genoppi, an open-source software for robust and standardized integration of proteomic and genetic data, facilitating comprehensive analysis in biological research.
Nature Communications (2021)
Research Highlights
Dr. Greta Pintacuda is a leading researcher at the Broad Institute, specializing in the intersection of genomics, neuroscience, and mental health. Her work focuses on understanding the molecular mechanisms underlying neurodevelopmental disorders and identifying potential therapeutic targets using cutting-edge techniques like iPSC models and proteomics.
Research Areas
BioinformaticsCrispr And Genetic EngineeringGeneticsRna Modifications And CancerRna Research And Splicing
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