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Hetian Lei
Assistant Professor at Research Department
Crispr And Genetic Engineering
Oncology
Retinal And Macular Surgery
Retinal Development And Disorders
Retinal Diseases And Treatments
2.1K
Citations
25
H-index
0
Patents
89
Publications
0
Grants
$0
Total Funding
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Research Contributions
Genome editing abrogates angiogenesis in vivo
Demonstrated the use of genome editing to successfully block angiogenesis in vivo, offering a potential therapeutic approach for diseases characterized by excessive blood vessel formation.
Nature Communications (2017)
A Novel Peptide Inhibits Tumor Growth by Blocking VEGF Binding
Identified a novel peptide that inhibits tumor growth and metastasis by interfering with the binding of Vascular Endothelial Growth Factor (VEGF) to its receptor.
Journal of Biological Chemistry (2002)
PDGF Receptor Signaling in Proliferative Vitreoretinopathy
Investigated the role of Platelet-Derived Growth Factor (PDGF) and its receptors in proliferative vitreoretinopathy (PVR), a serious eye disease.
Experimental Eye Research (2009)
CRISPR/Cas9-mediated depletion of VEGFR2 blocks angiogenesis in vitro
Showed that AAV-CRISPR/Cas9-mediated depletion of VEGFR2 can block angiogenesis in vitro, providing a potential therapeutic target for diseases involving abnormal blood vessel growth.
Investigative Ophthalmology & Visual Science (2017)
Exosomes mediate an epithelial-mesenchymal transition cascade in retinal pigment epithelial cells: Implications for proliferative vitreoretinopathy
Investigated the role of exosomes in mediating epithelial-mesenchymal transition (EMT) in retinal pigment epithelial cells, with implications for proliferative vitreoretinopathy.
Journal of Cellular and Molecular Medicine (2020)
Genome Editing of VEGFA Prevents Corneal Neovascularization In Vivo
Demonstrated that genome editing of VEGFA prevents corneal neovascularization in vivo, offering a potential therapeutic approach for corneal diseases.
Advanced Science (2024)
Research Highlights
Dr. Hetian Lei is an Assistant Professor at Xinxiang Medical University, specializing in retinal diseases and leveraging CRISPR technology and genome editing to develop novel therapeutic strategies. His research focuses on understanding the molecular mechanisms of angiogenesis and proliferative vitreoretinopathy.
Research Areas
Crispr And Genetic EngineeringOncologyRetinal And Macular SurgeryRetinal Development And DisordersRetinal Diseases And Treatments
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