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Researcher at Research Department
Ask questions about Holger Kramer's research, publications, and ongoing work
This seminal work, published in Science, revealed a novel function for Jmjd6 in RNA splicing through lysyl-hydroxylation of U2AF65, providing insights into RNA processing mechanisms.
This research, published in Chemistry & Biology, accelerated inhibitor development for deubiquitylating enzymes, offering new tools for drug discovery targeting the ubiquitin system.
Identified widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins, expanding the understanding of oxygen sensing mechanisms.
Kinetic investigations provided insights into the function of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an oxygen sensor, contributing to the understanding of cellular response to hypoxia.
Demonstrated the critical role of the UBL domain in stimulating the E3 ubiquitin ligase activity of UHRF1 toward chromatin, contributing to understanding epigenetic regulation.
Purified Smc5/6 complex exhibits DNA substrate recognition and compaction, contributing to understanding chromosome structure.
Dr. Holger Kramer is a leading researcher in proteomics and post-translational modifications, with significant contributions to understanding ubiquitin pathways, hypoxia response, and chromatin dynamics. His work has advanced the development of novel therapeutics and diagnostics.
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