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Jingshu Wang
Researcher at Research Department
And Metabolism
Artificial Intelligence
Estrogen And Related Hormone Effects
Hypoxia
Nf-Κb Signaling Pathways
Oncology
Rna Modifications And Cancer
2.3K
Citations
29
H-index
0
Patents
72
Publications
0
Grants
$0
Total Funding
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Research Contributions
Identified the role of Quercetin in suppressing Cyclooxygenase-2 (COX-2) expression and angiogenesis.
Demonstrated that quercetin inhibits COX-2 expression and angiogenesis by inactivating the P300 signaling pathway, providing insights into the anti-cancer properties of quercetin.
PLoS ONE (2011)
Investigated the simultaneous modulation of multiple signaling pathways by melatonin in breast cancer cells.
Showed that melatonin can simultaneously modulate COX-2, p300, Akt, and Apaf-1 signaling to inhibit proliferation and induce apoptosis in breast cancer cells, highlighting melatonin's potential as an anti-cancer agent.
Journal of Pineal Research (2012)
Elucidated the crosstalk between STAT3 and p53/RAS signaling in controlling cancer cell metastasis and cisplatin resistance.
Revealed that the interplay between STAT3 and p53/RAS signaling regulates epithelial-mesenchymal transition (EMT) and autophagy, impacting cancer cell metastasis and resistance to cisplatin.
Oncogenesis (2019)
Demonstrated the anti-cancer effects of berberine by targeting multiple signaling pathways.
Showed that berberine suppresses human cancer cell growth by targeting AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF, and Cytochrome-c/Caspase signaling pathways, indicating its potential as a therapeutic agent.
PLoS ONE (2013)
Showed that melatonin enhances the anti-tumor activity of berberine in lung cancer cells.
Demonstrated that melatonin potentiates the anti-tumor effects of berberine by modulating AP-2β/hTERT, NF-κB/COX-2, and Akt/ERK signaling, while activating caspase/Cyto C signaling.
Oncotarget (2015)
Investigated the role of melatonin in suppressing proinflammatory mediators.
Showed that melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated cells by targeting MAPK, NF-κB, c/EBPβ, and p300 signaling pathways.
Journal of Pineal Research (2012)
Identified the role of Palbociclib in inhibiting epithelial-mesenchymal transition and metastasis in breast cancer.
Demonstrated that palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via the c-Jun/COX-2 signaling pathway.
Oncotarget (2015)
Showed that melatonin enhances the anti-tumor effect of Fisetin.
Demonstrated that melatonin enhances the anti-tumor effect of Fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways.
PLoS ONE (2014)
Research Highlights
Dr. Jingshu Wang's research focuses on the molecular mechanisms of cancer, particularly exploring the role of signaling pathways and natural compounds in cancer cell growth, metastasis, and drug resistance. Her work has significantly contributed to understanding the interplay of various pathways in cancer and identifying potential therapeutic targets.
Research Areas
And MetabolismArtificial IntelligenceEstrogen And Related Hormone EffectsHypoxiaNf-Κb Signaling PathwaysOncologyRna Modifications And Cancer
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