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Justin Ainscough
Researcher at Research Department
Crispr And Genetic Engineering
Genetic Syndromes And Imprinting
Genetics
Pluripotent Stem Cells Research
3.3K
Citations
26
H-index
0
Patents
61
Publications
0
Grants
$0
Total Funding
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Research Contributions
Discovered Piezo1's role in vascular architecture
Identified Piezo1 as a key mechanotransducer integrating vascular architecture with physiological force, influencing vascular development and function.
Nature (2014)
Demonstrated H19's role as a trans regulator
Showed that the H19 gene acts as a trans regulator of the imprinted gene network, controlling growth in mice.
Development (2009)
Elucidated CIZ1's role in Xist RNA localization
Determined that the nuclear matrix protein CIZ1 facilitates the localization of Xist RNA to the inactive X-chromosome territory, contributing to X-chromosome inactivation.
Genes & Development (2017)
Identified CIZ1 as a circulating biomarker for lung cancer
Discovered that variant Ciz1 is a circulating biomarker for early-stage lung cancer, suggesting its potential for diagnostic applications.
Proceedings of the National Academy of Sciences (2012)
Characterized the role of TRPM2 channels in neuronal death after ischemia
Demonstrated that TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia, suggesting a therapeutic target for stroke.
Cell Death and Disease (2014)
Showed that maintenance of epigenetic landscape requires CIZ1
Demonstrated that maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture.
Nature Communications (2019)
Discovered that prion-like domains drive CIZ1 assembly formation at the inactive X chromosome
Showed that prion-like domains drive CIZ1 assembly formation at the inactive X chromosome, contributing to understanding of chromosome inactivation.
The Journal of Cell Biology (2022)
Research Highlights
Dr. Ainscough is a leading researcher in genomic imprinting, stem cell biology, and the role of CIZ1 in DNA replication and cancer. His work has significantly advanced our understanding of epigenetic mechanisms and their implications for development and disease.
Research Areas
Crispr And Genetic EngineeringGenetic Syndromes And ImprintingGeneticsPluripotent Stem Cells Research
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