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Kin Fai Au
Professor at Computational Medicine and Bioinformatics
Cancer-Related Molecular Mechanisms Research
Genetics
Molecular Biology Techniques And Applications
Rna Modifications And Cancer
Rna Research And Splicing
7.4K
Citations
27
H-index
0
Patents
62
Publications
2
Grants
$1,097,079
Total Funding
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Research Contributions
Developed SpliceMap for detecting splice junctions from RNA-seq data
Developed SpliceMap, a tool for identifying splice junctions from paired-end RNA-seq data, significantly improving the accuracy of transcriptome analysis.
Nucleic Acids Research (2010)
Pioneered hybrid sequencing approaches for transcriptome analysis
Developed and applied hybrid sequencing methods, combining short-read and long-read sequencing, to characterize the transcriptome of human embryonic stem cells and other biological systems.
Proceedings of the National Academy of Sciences (2013)
Comprehensive comparison of PacBio and Nanopore sequencing technologies
Conducted a comprehensive comparison of Pacific Biosciences and Oxford Nanopore Technologies, providing valuable insights into their strengths and limitations for transcriptome analysis.
F1000Research (2017)
Advanced long-read RNA-seq methods for transcript identification and quantification
Systematically assessed long-read RNA-seq methods, improving transcript identification and quantification, and contributing to a deeper understanding of transcriptome complexity.
Nature Methods (2024)
Discovered the role of HPAT5 in regulating pluripotency
Identified the primate-specific noncoding RNA HPAT5 and demonstrated its role in regulating pluripotency during human preimplantation development and nuclear reprogramming.
Nature Genetics (2015)
Developed IDP-ASE for allele-specific expression quantification
Created IDP-ASE, a tool for haplotyping and quantifying allele-specific expression at the gene and gene isoform level using hybrid sequencing data.
Nucleic Acids Research (2016)
Improved PacBio long read accuracy by short read alignment
Developed a method to improve the accuracy of PacBio long reads by aligning them with short reads, enhancing the reliability of long-read sequencing data.
PLoS ONE (2012)
Investigated the RNA m6A landscape in oocytes and preimplantation embryos
Characterized the RNA m6A landscape in mouse oocytes and preimplantation embryos, providing insights into the role of RNA modifications in early development.
Nature Structural & Molecular Biology (2023)
Research Highlights
Kin Fai Au is a leading expert in computational medicine and bioinformatics, focusing on the development and application of novel sequencing technologies for transcriptome analysis and understanding disease mechanisms. His work has significantly advanced the fields of long-read sequencing, RNA splicing, and cancer genomics.
Research Areas
Cancer-Related Molecular Mechanisms ResearchGeneticsMolecular Biology Techniques And ApplicationsRna Modifications And CancerRna Research And Splicing
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