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Martin W. Hetzer
Researcher at Research Department
Artificial Intelligence
Genetics
Nuclear Structure And Function
Rna Regulation And Disease
Rna Research And Splicing
12.5K
Citations
55
H-index
0
Patents
94
Publications
0
Grants
$0
Total Funding
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Research Contributions
Discovered the age-dependent deterioration of nuclear pore complexes
Demonstrated that the age-dependent deterioration of nuclear pore complexes leads to a loss of nuclear integrity in postmitotic cells, contributing to cellular aging.
Cell (2009)
Identified long-lived proteins in essential cellular structures
Identified and characterized long-lived proteins within cells, revealing the exceptional stability of essential cellular structures and their role in cellular maintenance.
Cell (2013)
Characterized catastrophic nuclear envelope collapse in cancer cell micronuclei
Showed that micronuclei in cancer cells undergo catastrophic nuclear envelope collapse, contributing to genomic instability and cancer progression.
Cell (2013)
Demonstrated chromatin-bound nuclear pore components regulate gene expression
Revealed that nuclear pore components bound to chromatin play a crucial role in regulating gene expression in higher eukaryotes, linking nuclear transport to transcriptional control.
Cell (2010)
Elucidated the role of Nup153 in embryonic stem cell pluripotency
Demonstrated that the nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing, highlighting the importance of nuclear pore proteins in stem cell biology.
Genes & Development (2015)
Discovered lifelong persistence of nuclear RNAs in the mouse brain
Identified a population of exceptionally stable, long-lived nuclear RNAs in the mouse brain, challenging the conventional view of RNA turnover and suggesting a role in long-term cellular function.
Science (2024)
Research Highlights
Martin W. Hetzer is a leading cell biologist renowned for his work on nuclear pore complexes, cellular aging, and genome regulation. His research has significantly advanced our understanding of nuclear transport, protein homeostasis, and the role of the nuclear envelope in development and disease.
Research Areas
Artificial IntelligenceGeneticsNuclear Structure And FunctionRna Regulation And DiseaseRna Research And Splicing
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