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Mehmet Ay
Prof. & Head of Organic Chemistry Division at Chemistry
Catalytic Cross-Coupling Reactions
Chemical Synthesis And Analysis
Click Chemistry And Applications
Drug Discovery
Phytochemicals And Antioxidant Activities
1.3K
Citations
18
H-index
0
Patents
61
Publications
0
Grants
$0
Total Funding
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Research Contributions
Pioneering work on electrophilic amination of carbanions
Developed a novel method for electrophilic amination of carbanions, a fundamental reaction in organic synthesis, with broad applications in the synthesis of complex molecules.
Chemical Reviews (1989)
Discovery of a new flavone from antioxidant extracts of Pistacia terebinthus
Identified and characterized a novel flavone compound with significant antioxidant activity from the extracts of Pistacia terebinthus, contributing to the understanding of natural antioxidants.
Food Chemistry (2006)
Development of highly stereoselective synthesis of (z)-3-methyl-2-alken-1-ols
Developed a highly stereoselective and general synthesis of (z)-3-methyl-2-alken-1-ols via palladium-catalyzed cross-coupling, providing a valuable method for synthesizing complex organic molecules.
Tetrahedron Letters (1993)
Synthesis of novel nimesulide derivatives with selective COX-2 inhibition and antitumor effects
Synthesized and evaluated novel nimesulide derivatives, demonstrating selective COX-2 inhibition and antitumor effects, contributing to the development of potential anti-inflammatory and anticancer agents.
European Journal of Medicinal Chemistry (2021)
Design and synthesis of novel coumarin carboxamide derivatives as eEF-2K inhibitors
Designed, synthesized, and studied novel coumarin carboxamide derivatives as inhibitors of eukaryotic elongation factor 2 kinase (eEF-2K), a potential target for cancer therapy.
Journal of Chemical Information and Modeling (2020)
Research on prodrugs for nitroreductase-based cancer therapy
Investigated the development of prodrugs activated by nitroreductases for targeted cancer therapy, including the synthesis and evaluation of novel dinitroaniline prodrugs.
European Journal of Medicinal Chemistry (2019)
Identification of antioxidant phenolic compounds from Erica arborea
Identified and characterized antioxidant phenolic compounds from the leaves of Erica arborea, contributing to the understanding of natural antioxidants and their potential health benefits.
Natural Product Research (2008)
Research Highlights
Professor Mehmet Ay is a leading researcher in organic chemistry, specializing in the synthesis and analysis of bioactive compounds, particularly those with antioxidant and anticancer properties. His work includes pioneering research on prodrugs for targeted cancer therapy and the development of novel inhibitors.
Research Areas
Catalytic Cross-Coupling ReactionsChemical Synthesis And AnalysisClick Chemistry And ApplicationsDrug DiscoveryPhytochemicals And Antioxidant Activities
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