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Sahaana Chandran - Cancer Genomics & Epigenetics Research

Sahaana Chandran

Researcher at Research Department

Diagnostics

Genetics

Glioma Diagnosis And Treatment

Rna Research And Splicing

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Research Contributions

Developed a technique to simultaneously profile 3D genome structure and DNA methylation in single human cells.

This work, published in Nature Methods, enabled a deeper understanding of the relationship between genome structure and epigenetic modifications.

Nature Methods (2019)

Discovered that somatic genomic rearrangements disrupt chromatin folding domains in human cancer.

This research, published in Nature Genetics, provided insights into how structural variations contribute to cancer development.

Nature Genetics (2020)

Identified the role of circular extrachromosomal DNA in promoting tumor heterogeneity in high-risk medulloblastoma.

This study, published in Nature Genetics, revealed a mechanism for tumor evolution and potential therapeutic targets.

Nature Genetics (2023)

Mapped genome repair sites in postmitotic human neurons using a nucleoside analog.

This work, published in Science, provided a novel approach to study DNA repair mechanisms in the brain.

Science (2021)

Showed that 3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma.

This research, published in Nature Communications, identified potential therapeutic targets for ependymoma.

Nature Communications (2023)

Demonstrated that structural variants drive context-dependent oncogene activation in cancer.

This work, published in Nature, provided insights into how structural variations contribute to cancer development.

Nature (2022)

Research Highlights

Dr. Sahaana Chandran is a leading researcher in cancer genomics and epigenetics, with significant contributions to understanding 3D genome structure, DNA methylation, and their roles in cancer development and treatment. Her work has identified novel therapeutic targets and advanced the understanding of tumor heterogeneity.

Research Areas

DiagnosticsGeneticsGlioma Diagnosis And TreatmentRna Research And Splicing

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