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Sumia A. Bageghni
Lecturer of Physiology at Optometry and Vision Sciences
Biomedical Engineering
Cardiac Fibrosis And Remodeling
Crispr And Genetic Engineering
Genetics
Signaling Pathways In Disease
355
Citations
5
H-index
0
Patents
9
Publications
0
Grants
$0
Total Funding
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Research Contributions
IL-1 receptor-1 deletion reduces adverse cardiac remodeling
Demonstrated that fibroblast-specific deletion of IL-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction, providing a potential therapeutic target.
JCI Insight (2019)
Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy
Identified that cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a paracrine interleukin-6 signaling mechanism, offering insights into hypertrophy mechanisms.
The FASEB Journal (2018)
CIZ1 facilitates Xist RNA localization
Showed that the nuclear matrix protein CIZ1 facilitates the localization of Xist RNA to the inactive X-chromosome territory, contributing to understanding X-chromosome inactivation.
Genes & Development (2017)
11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment
Investigated the role of 11β-HSD1 in suppressing cardiac fibroblast activity and neutrophil recruitment after myocardial infarction.
Journal of Endocrinology (2017)
CIZ1 stimulates mononucleated cell production
Demonstrated that cardiomyocyte-specific expression of CIZ1 stimulates the production of mononucleated cells with an extended window of proliferation in the postnatal mouse heart.
Biology Open (2016)
Functional differences in human cardiac fibroblasts
Investigated inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors.
Cardiovascular Pathology (2014)
MiR-214-3p regulates Piezo1, lysyl oxidases and mitochondrial function
Investigated the role of MiR-214-3p in regulating Piezo1, lysyl oxidases and mitochondrial function in human cardiac fibroblasts.
Matrix Biology (2024)
Research Highlights
Dr. Sumia Bageghni's research focuses on the cellular and molecular mechanisms of cardiovascular disease, particularly cardiac fibrosis and remodeling, with a focus on fibroblast biology and signaling pathways. Her work has contributed to understanding the role of specific proteins and pathways in heart disease.
Research Areas
Biomedical EngineeringCardiac Fibrosis And RemodelingCrispr And Genetic EngineeringGeneticsSignaling Pathways In Disease
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