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Tatyana B. Nesterova

Researcher at Dept. of Biochemistry

Chromosomal And Genetic Variations

Crispr And Genetic Engineering

Genetic And Clinical Aspects Of Sex Determination And Chromosomal Abnormalities

Genetics

Rna Modifications And Cancer

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Research Contributions

Identified the role of Ring1A/B proteins in linking histone ubiquitylation to heritable gene silencing and X inactivation.

This work elucidated the mechanism by which Polycomb group proteins mediate gene silencing during X inactivation.

Developmental Cell (2004)

Demonstrated the functional association of cohesins with CTCF on mammalian chromosome arms.

This research provided insights into the role of cohesins in chromosome organization and function.

Cell (2008)

Showed that establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 Polycomb Group complexes.

This study identified key factors involved in initiating and maintaining the epigenetic modifications on the inactive X chromosome.

Developmental Cell (2003)

Investigated the reactivation of the paternal X chromosome in early mouse embryos.

This research explored the dynamics of X chromosome inactivation and reactivation during early development.

Science (2004)

Identified hnRNPK as a recruiter of PCGF3/5-PRC1 to the Xist RNA B-Repeat to establish Polycomb-mediated chromosomal silencing.

This work revealed the mechanism of PRC1 recruitment to the Xist RNA, which is crucial for X chromosome inactivation.

Molecular Cell (2017)

Showed that PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation.

This study highlighted the role of PCGF3/5–PRC1 in initiating Polycomb recruitment during X chromosome inactivation.

Science (2017)

Demonstrated that Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

This research elucidated the interplay between PRC1 and PRC2 complexes in regulating gene silencing.

Nature Communications (2016)

Identified Rbm15, Spen, and Wtap as factors required for Xist RNA-mediated silencing using a pooled shRNA screen.

This study identified novel factors involved in Xist RNA-mediated silencing.

Cell Reports (2015)

Showed that stabilization of Xist RNA mediates initiation of X chromosome inactivation.

This research highlighted the importance of Xist RNA stabilization in initiating X chromosome inactivation.

Cell (1997)

Research Highlights

Dr. Tatyana B. Nesterova is a leading researcher in the field of X chromosome inactivation, with significant contributions to understanding the epigenetic mechanisms governing gene silencing and chromosome structure. Her work has advanced our knowledge of how these processes impact development and disease.

Research Areas

Chromosomal And Genetic VariationsCrispr And Genetic EngineeringGenetic And Clinical Aspects Of Sex Determination And Chromosomal AbnormalitiesGeneticsRna Modifications And Cancer

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Tatyana B. Nesterova - Expert in X Chromosome Inactivation | Oxford