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Xin Chen
Assistant Professor at Pharmaceutical Sciences
Cancer-Related Gene Regulation
Genetics
Neuroblastoma Research And Treatments
Receptor Mechanisms And Signaling
Single-Cell And Spatial Transcriptomics
7.1K
Citations
38
H-index
0
Patents
99
Publications
8
Grants
$3,172,046
Total Funding
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Research Contributions
Identified Dynamic Kinome Reprogramming in Triple-Negative Breast Cancer
Demonstrated dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer, providing insights into resistance mechanisms.
Cell (2012)
Developed Chemical Probe Selectively Inhibiting G9a and GLP Methyltransferase Activity
Created a chemical probe that selectively inhibits G9a and GLP methyltransferase activity in cells, offering a tool for epigenetic studies and drug development.
Nature Chemical Biology (2011)
Unsilenced Dormant Ube3a Allele in Neurons Using Topoisomerase Inhibitors
Showed that topoisomerase inhibitors can unsilence the dormant allele of Ube3a in neurons, suggesting potential therapeutic strategies for Angelman syndrome.
Nature (2011)
Discovered β-Arrestin-Biased Dopamine D2 Ligands for Antipsychotic Efficacy
Identified β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy, contributing to the development of safer antipsychotics.
Proceedings of the National Academy of Sciences (2011)
Targeting BET Family Bromodomains Inhibits Lapatinib-Induced Kinome Reprogramming
Demonstrated that targeting BET family bromodomains inhibits lapatinib-induced kinome reprogramming in ERBB2-positive breast cancer, offering a combination therapy approach.
Cell Reports (2015)
Identified Allosteric Ligands for the Pharmacologically Dark Receptors GPR68 and GPR65
Discovered allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65, expanding the understanding of GPCR signaling and potential drug targets.
Nature (2015)
Developed Potent and Selective Inhibitors of Histone Lysine Methyltransferase G9a
Discovered a 2,4-Diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a, providing a valuable tool for epigenetic research.
Journal of Medicinal Chemistry (2009)
Elucidated Enhancer Remodeling during Adaptive Bypass to MEK Inhibition
Showed that enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex, suggesting a strategy to overcome drug resistance.
Cancer Discovery (2017)
Research Highlights
Xin Chen is an Assistant Professor at Shenzhen University, specializing in pharmaceutical sciences with expertise in cancer-related gene regulation, epigenetics, and receptor signaling. Her research focuses on drug discovery and development, contributing significantly to understanding kinome reprogramming and identifying novel therapeutic targets.
Research Areas
Cancer-Related Gene RegulationGeneticsNeuroblastoma Research And TreatmentsReceptor Mechanisms And SignalingSingle-Cell And Spatial Transcriptomics
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