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Researcher at reproduction medicine center
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Demonstrated that baicalin attenuates oxygen-glucose deprivation/reoxygenation-induced injury in neuron-astrocyte cocultures by modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 signaling axes.
Showed that geniposide protects against hypoxia/reperfusion-induced blood-brain barrier impairment by increasing tight junction protein expression and decreasing inflammation, oxidative stress, and apoptosis.
Investigated the protective effects of melatonin against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency through the ERK signaling pathway in CHO cells.
Found that asperosaponin VI promotes progesterone receptor expression in decidual cells via the notch signaling pathway.
Demonstrated that lentinan triggers oxidative stress-mediated anti-inflammatory responses in lung cancer cells.
Showed that nigericin boosts anti-tumor immune response via inducing pyroptosis in triple-negative breast cancer.
Investigated that PPAR-alpha inhibits DHEA-induced ferroptosis in granulosa cells through upregulation of FADS2.
Dr. Xin Du's research focuses on the molecular mechanisms of disease, particularly in cancer and reproductive health, with a focus on therapeutic interventions and the role of signaling pathways.
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