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Researcher at Research Department
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Demonstrated that transcription factor Foxo1 negatively regulates natural killer cell maturation and function, providing insights into immune regulation.
Elucidated the crosstalk between mTORC1 and mTORC2 signaling pathways in controlling NK cell maturation and effector function through cytokine signaling.
Evaluated the antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice, highlighting their therapeutic applications.
Showed that the omega-3 polyunsaturated fatty acid docosahexaenoic acid enhances NK-cell antitumor effector functions, suggesting a role in cancer immunotherapy.
Discovered that mTOR signaling promotes rapid m6A mRNA methylation to regulate NK-cell activation and effector functions, revealing a novel regulatory mechanism.
Demonstrated that maternal inflammation activates ROS-p38 MAPK, predisposing offspring to heart damages and hypertension via augmenting ROS generation.
Characterized the unique phenotypes of heart resident type 2 innate lymphoid cells, contributing to the understanding of cardiac immunology.
Yafei Deng is a leading researcher in immunology and pharmacology, focusing on the role of immune cells, particularly NK cells and ILCs, in cancer and inflammatory diseases. Her work also explores the therapeutic potential of traditional Chinese medicines and omega-3 fatty acids in various health conditions.
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