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Yu Zhang
Researcher at Research Department
Crispr And Genetic Engineering
Genetics
Heavy Metals In Environment
Muscle Physiology And Disorders
1.4K
Citations
17
H-index
0
Patents
39
Publications
4
Grants
$1,721,833
Total Funding
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Research Contributions
CRISPR-Cpf1 correction of muscular dystrophy mutations
Developed a CRISPR-Cpf1 system to correct muscular dystrophy mutations in human cardiomyocytes and mice, demonstrating the potential for therapeutic genome editing.
Science Advances (2017)
Correction of diverse muscular dystrophy mutations in human engineered heart muscle
Successfully corrected diverse muscular dystrophy mutations in human engineered heart muscle using single-site genome editing, paving the way for personalized medicine approaches.
Science Advances (2018)
Enhanced CRISPR-Cas9 correction of Duchenne muscular dystrophy
Improved CRISPR-Cas9 correction of Duchenne muscular dystrophy in mice using a self-complementary AAV delivery system, enhancing therapeutic efficacy.
Science Advances (2020)
Base editing correction of hypertrophic cardiomyopathy
Utilized base editing to correct hypertrophic cardiomyopathy mutations in human cardiomyocytes and humanized mice, offering a novel therapeutic strategy.
Nature Medicine (2023)
Precise genomic editing rescues dilated cardiomyopathy
Demonstrated that precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy, providing a potential treatment.
Science Translational Medicine (2022)
Development of a new immuno-, dystrophin-deficient mouse model
Created a novel mouse model (NSG-mdx 4Cv) to study muscular dystrophy and demonstrated functional improvement following allogeneic satellite cell transplantation.
Stem Cells (2013)
Research Highlights
Dr. Yu Zhang is a leading researcher in genome editing, specializing in CRISPR-based therapies for muscular dystrophy and cardiovascular diseases. His work focuses on developing innovative gene editing approaches to correct genetic mutations and improve disease outcomes.
Research Areas
Crispr And Genetic EngineeringGeneticsHeavy Metals In EnvironmentMuscle Physiology And Disorders
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