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Yuwei Xu - Immunology, Pharmacology, and Cancer Research | Zhejiang University

Yuwei Xu

Researcher at Research Department

Cancer-Related Molecular Mechanisms Research

Helicobacter Pylori-Related Gastroenterology Studies

Immune Cell Function And Interaction

Medicinal Plant Pharmacodynamics Research

Microrna In Disease Regulation

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Research Contributions

Identified N-undecanoylglycine as a bacterial metabolite sensed by intestinal Tuft-2 cells, triggering antimicrobial immunity.

This study revealed a novel mechanism of intestinal immunity, identifying a specific bacterial metabolite that activates immune responses in the gut.

Immunity (2022)

Demonstrated that Icariin and its derivatives alleviate intestinal epithelial barrier disruption caused by enterotoxigenic E. coli.

This research highlighted the protective effects of Icariin on gut health, showing its potential in treating intestinal damage.

The FASEB Journal (2019)

Showed that Berberine modulates the NF-κB/MAPK signaling pathway and related inflammatory cytokines in porcine intestinal epithelial cells.

This work investigated the anti-inflammatory effects of Berberine, providing insights into its mechanism of action in the gut.

Innate Immunity (2020)

Investigated the protective effects of Icariin and phosphorylated Icariin against LPS-induced intestinal epithelial cell injury.

This study explored the therapeutic potential of Icariin in protecting intestinal cells from damage.

Biomedicine & Pharmacotherapy (2019)

Found that Ligustilide inhibits the activation of cancer-associated fibroblasts.

This research identified Ligustilide as a potential therapeutic agent for cancer by targeting cancer-associated fibroblasts.

Life Sciences (2018)

Demonstrated that Cinnamaldehyde treatment of prostate cancer-associated fibroblasts prevents their inhibitory effect on T cells.

This study revealed the immunomodulatory effects of Cinnamaldehyde in the tumor microenvironment.

Drug Design Development and Therapy (2020)

Showed that Icariin enhances intestinal barrier function by modulating gut microbiota in a piglet model.

This research highlighted the role of Icariin in improving gut health by modulating the gut microbiota.

RSC Advances (2019)

Research Highlights

Dr. Yuwei Xu's research focuses on the intersection of immunology and pharmacology, with a strong emphasis on the role of natural compounds and signaling pathways in modulating immune responses and cancer progression. His work has significantly contributed to understanding the mechanisms of intestinal barrier function and the development of novel therapeutic strategies.

Research Areas

Cancer-Related Molecular Mechanisms ResearchHelicobacter Pylori-Related Gastroenterology StudiesImmune Cell Function And InteractionMedicinal Plant Pharmacodynamics ResearchMicrorna In Disease Regulation

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