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Researcher at Research Department
Ask questions about Zhe Wang's research, publications, and ongoing work
Identified the role of increased tumor glycolysis in mediating immune resistance to adoptive T cell therapy, providing insights into improving treatment efficacy.
Conducted a Phase I clinical trial evaluating the safety and efficacy of CAR-T cell therapy targeting CEA+ metastatic colorectal cancers, contributing to the development of novel cancer treatments.
Developed albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy, enhancing immune responses and therapeutic outcomes.
Investigated the role of Twist2 in breast cancer progression, demonstrating its contribution to epithelial-mesenchymal transition and cancer stem cell self-renewal.
Demonstrated that the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses, providing insights into immune responses.
Showed that Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumor metastasis, contributing to understanding of metastasis.
Showed that extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness, providing insights into T cell behavior.
Demonstrated that mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity, providing insights into T cell behavior.
Dr. Zhe Wang is a leading researcher in cancer immunotherapy and drug development, with significant contributions to CAR-T cell therapy and understanding tumor microenvironments. His work has advanced the field of oncology, particularly in the areas of metastasis and immune resistance.
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